Abstract: Biomedical (or laboratory-based, basic science-driven) (BM) research is no longer a novel or an ignored field of public health (PH) in member countries of the SAARC region. However, as compared to big scientific powerhouses globally, Nepal has a long way to go to make BM research mainstream in the PH sector. Understanding of the pathogens that cause certain diseases, and also issues of human immunity that play roles in both communicable and non-communicable diseases (NCDs- such as cancers, diabetes etc.) is an integral part of BM research. In Nepal, there appears to be a changing trend of approach to BM research in terms of human resource involved and the technology/infrastructure available to carry out those research activities. Medical and nonmedical sectors are now showing active participation in carrying out BM research in the country. Yet, challenges remain to effectively utilize the knowledge of BM research as well as use of this research to support ongoing disease surveillance in the country. This talk discusses these issues and briefly showcases the role of a research institution based in Nepal- which is now generating interest in the country (and also outside) in this field of science and public health.